Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation
Identifieur interne : 000B25 ( Main/Exploration ); précédent : 000B24; suivant : 000B26Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation
Auteurs : Tultul Nayyar [États-Unis] ; Michael Bubser [États-Unis] ; Marcus C. Ferguson [États-Unis] ; M. Diana Neely [États-Unis] ; J. Shawn Goodwin [États-Unis] ; Thomas J. Montine [États-Unis] ; Ariel Y. Deutch [États-Unis] ; Twum A. Ansah [États-Unis]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 2009-07.
English descriptors
Abstract
Parkinson’s Disease (PD) is marked by prominent motor symptoms that reflect striatal dopamine insufficiency. However, non‐motor symptoms, including depression, are common in PD. It has been suggested that these changes reflect pathological involvement of non‐dopaminergic systems. We examined regional changes in serotonin (5‐HT) and norepinephrine (NE) systems in mice treated with two different 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) treatment paradigms, at survival times of 3 or 16 weeks after the last MPTP injection. MPTP caused a decrease in striatal dopamine concentration, the magnitude of which depended on the treatment regimen and survival interval after MPTP treatment. There was significant involvement of other subcortical areas receiving a dopamine innervation, but no consistent changes in 5‐HT or NE levels in subcortical sites. In contrast, we observed an enduring decrease in 5‐HT and NE concentrations in both the somatosensory cortex and medial prefrontal cortex (PFC). Immunohistochemical studies also revealed a decrease in the density of PFC NE and 5‐HT axons. The decrease in the cortical serotonergic innervation preferentially involved the thick beaded but not smooth fine 5‐HT axons. Similar changes in the 5‐HT innervation of post‐mortem samples of the PFC from idiopathic PD cases were seen. Our findings point to a major loss of the 5‐HT and NE innervations of the cortex in MPTP‐induced parkinsonism, and suggest that loss of the beaded cortical 5‐HT innervation is associated with a predisposition to the development of depression in PD.
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DOI: 10.1111/j.1460-9568.2009.06806.x
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However, non‐motor symptoms, including depression, are common in PD. It has been suggested that these changes reflect pathological involvement of non‐dopaminergic systems. We examined regional changes in serotonin (5‐HT) and norepinephrine (NE) systems in mice treated with two different 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) treatment paradigms, at survival times of 3 or 16 weeks after the last MPTP injection. MPTP caused a decrease in striatal dopamine concentration, the magnitude of which depended on the treatment regimen and survival interval after MPTP treatment. There was significant involvement of other subcortical areas receiving a dopamine innervation, but no consistent changes in 5‐HT or NE levels in subcortical sites. In contrast, we observed an enduring decrease in 5‐HT and NE concentrations in both the somatosensory cortex and medial prefrontal cortex (PFC). Immunohistochemical studies also revealed a decrease in the density of PFC NE and 5‐HT axons. The decrease in the cortical serotonergic innervation preferentially involved the thick beaded but not smooth fine 5‐HT axons. Similar changes in the 5‐HT innervation of post‐mortem samples of the PFC from idiopathic PD cases were seen. Our findings point to a major loss of the 5‐HT and NE innervations of the cortex in MPTP‐induced parkinsonism, and suggest that loss of the beaded cortical 5‐HT innervation is associated with a predisposition to the development of depression in PD.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li><li>Washington (État)</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Nayyar, Tultul" sort="Nayyar, Tultul" uniqKey="Nayyar T" first="Tultul" last="Nayyar">Tultul Nayyar</name></region><name sortKey="Ansah, Twum A" sort="Ansah, Twum A" uniqKey="Ansah T" first="Twum A." last="Ansah">Twum A. Ansah</name><name sortKey="Bubser, Michael" sort="Bubser, Michael" uniqKey="Bubser M" first="Michael" last="Bubser">Michael Bubser</name><name sortKey="Deutch, Ariel Y" sort="Deutch, Ariel Y" uniqKey="Deutch A" first="Ariel Y." last="Deutch">Ariel Y. Deutch</name><name sortKey="Diana Neely, M" sort="Diana Neely, M" uniqKey="Diana Neely M" first="M." last="Diana Neely">M. Diana Neely</name><name sortKey="Ferguson, Marcus C" sort="Ferguson, Marcus C" uniqKey="Ferguson M" first="Marcus C." last="Ferguson">Marcus C. Ferguson</name><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name><name sortKey="Shawn Goodwin, J" sort="Shawn Goodwin, J" uniqKey="Shawn Goodwin J" first="J." last="Shawn Goodwin">J. Shawn Goodwin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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